Flentge, Charles A.: search on Z-Library

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1

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Kempf, Dale J., Sham, Hing L., Marsh, Kennan C., Flentge, Charles A., Betebenner, David, Green, Brian E., McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E., Kati, Warren M.,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 189 KB

english, 1998

2

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 706 KB

english, 2013

3

Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase

Yaya Liu, Ben Hock Lim, Wen W. Jiang, Charles A. Flentge, Douglas K. Hutchinson, Darold L. Madigan, John T. Randolph, Rolf Wagner, Clarence J. Maring, Warren M. Kati, Akhteruzzaman Molla

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

4

Discovery of Fluorobenzimidazole HCV NS5A Inhibitors

Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Kri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 872 KB

english, 2016

5

Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease

Dale J. Kempf, Charles A. Flentge, Norman E. Wideburg, Ayda Saldivar, Sudthida Vasavanonda, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 225 KB

english, 1995

6

Oximinoarylsulfonamides as potent HIV protease inhibitors

Clinton M. Yeung, Larry L. Klein, Charles A. Flentge, John T. Randolph, Chen Zhao, MingHua Sun, Tatyana Dekhtyar, Vincent S. Stoll, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 185 KB

english, 2005

7

2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects†

DeGoey, David A., Grampovnik, David J., Flentge, Charles A., Flosi, William J., Chen, Hui-ju, Yeung, Clinton M., Randolph, John T., Klein, Larry L., Dekhtyar, Tatyana, Colletti, Lynn

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 333 KB

english, 2009

8

Decomposition of solid peroxydisulfates

J.E. House Jr., Charles Flentge

Journal:

Thermochimica Acta

Year:

1978

Language:

english

File:

PDF, 211 KB

english, 1978

9

ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans

Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen, Edith McDonald, Sudthida Vasavanonda, Charles A. Flentge, Brian E. Green, Lynnmarie Fino, Chang H. Park, Xiang-Peng Kong, Norman E. Wideburg, Ayda Sald

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

10

A study of propellant decomposition by differential scanning calorimetry

J.E. House Jr., Charles Flentge, Paul J. Zack

Journal:

Thermochimica Acta

Year:

1978

Language:

english

File:

PDF, 430 KB

english, 1978

11

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs

Charles A. Flentge, John T. Randolph, Peggy P. Huang, Larry L. Klein, Kennan C. Marsh, John E. Harlan, Dale J. Kempf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 345 KB

english, 2009

12

Synthesis and Biological Characterization of B-Ring Amino Analogues of Potent Benzothiadiazine Hepatitis C Virus Polymerase Inhibitors

Randolph, John T., Flentge, Charles A., Huang, Peggy P., Hutchinson, Douglas K., Klein, Larry L., Lim, Hock B., Mondal, Rubina, Reisch, Thomas, Montgomery, Debra A., Jiang, Wen W., Masse, Sherie V., H

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 512 KB

english, 2009

13

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease

Dale J. Kempf, Akhteruzzaman Molla, Kennan C. Marsh, Chang Park, A.David Rodrigues, Marina Korneyeva, Sudthida Vasavanonda, Edith McDonald, Charles A. Flentge, Steven Muchmore, Norman E. Wideburg, Ayd

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 305 KB

english, 1997

14

Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety

Douglas K. Hutchinson, Charles A. Flentge, Pamela L. Donner, Rolf Wagner, Clarence J. Maring, Warren M. Kati, Yaya Liu, Sherie V. Masse, Tim Middleton, Hongmei Mo, Debra Montgomery, Wen W. Jiang, Genn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 410 KB

english, 2011

15

Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors

John T. Randolph, Peggy P. Huang, William J. Flosi, David DeGoey, Larry L. Klein, Clinton M. Yeung, Charles Flentge, Mingua Sun, Chen Zhao, Tatyana Dekhtyar, Hongmei Mo, Lynn Colletti, Warren Kati, Ke

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

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